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Emerging ultrafast technologies in biotechnology.

Israt Jahan1, Mohammad Harun-Ur-Rashid2, Mohammed S Almuhayawi3

  • 1Air Quality and Environmental Pollution Research Laboratory (AQEPRL), Centre for Advanced Research in Sciences (CARS), University of Dhaka, 1000, Dhaka, Bangladesh.

3 Biotech
|April 28, 2025
PubMed
Summary

Ultrafast technologies like femtosecond lasers and spectroscopy revolutionize biotechnology by enabling real-time visualization and precise manipulation of biomolecular processes, advancing gene editing and disease understanding.

Keywords:
BiotechnologyGene editingUltrafast imagingUltrafast lasersUltrafast spectroscopyUltrafast technologies

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Area of Science:

  • Biotechnology
  • Biophysics
  • Molecular Biology

Background:

  • Biotechnology relies on precise tools for molecular processes.
  • Understanding complex biological systems requires advanced imaging and manipulation techniques.

Purpose of the Study:

  • To review the transformative applications of ultrafast technologies in biotechnology.
  • To highlight advancements in real-time visualization and manipulation of biomolecular processes.

Main Methods:

  • Femtosecond laser applications in gene editing.
  • Ultrafast spectroscopy for protein folding and enzymatic activity studies.
  • Advanced imaging techniques like pump-probe microscopy and CARS microscopy.
  • Attosecond spectroscopy for electron dynamics.

Main Results:

  • Enhanced precision in gene editing with minimized off-target effects.
  • Detailed insights into protein folding intermediates and enzymatic catalysis.
  • Real-time monitoring systems for gene editing.
  • High-resolution observation of cellular dynamics and neural activity.
  • Unprecedented understanding of ultrafast electron dynamics.

Conclusions:

  • Integration of ultrafast technologies with AI and nanotechnology accelerates diagnostics, personalized medicine, and synthetic biology.
  • Ongoing advancements promise to revolutionize biotechnology, addressing critical healthcare challenges.
  • Potential for transformative progress in understanding and treating complex diseases.