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Updated: Jul 14, 2026
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
Published on: September 11, 2012
Suppressor effects of carrots on azoxymethane/dextran sulfate sodium-induced colon cancer according to cultivation
Yanni Pan1, Yeon-Jun Lee2, Jin Hyeop Kim2
1Collaborative Innovation Center for Child Nutrition and Health Development, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing, China.
Introduction:
This study investigated the suppressor effects of carrots depending on cultivation method on AOM/DSS-induced colon cancer in mice by examining cell apoptosis, inflammation response, and metabolites. Carrots grown using different fertilizers significantly suppressed tumor development by modulating cell apoptosis and inflammatory responses in our experimental settings.
Methods And Results:
Naturaldream Fertilizer Carrot (NFC) cultivated with deep sea water minerals (DSWM) showed effectively increased the expression of apoptosis-related genes and proteins including p53, p21, Bim, Bad, Bax, Bak, Caspase 9, and Caspase 3 in colon tissue, while inhibiting the production of inflammatory factors and related genes and proteins such as TNF-a, IL-1b, IL-6, IFN-g, NF-kB, and iNOS in serum, spleen cells, and liver tissues. Intestinal microbiota analysis revealed a distinct composition in mice receiving carrots compared to the control group, with accumulation of intestinal microorganisms such as Lachnospiraceae, and Mucispirillum schaedleri closely associated with anti-tumor effects.
Discussion And Conclusion:
Overall, our results indicate that carrots, especially carrots grown with DSWM fertilizers, play a crucial role in inhibiting AOM/DSS-induced colon cancer in mice by regulating cell apoptosis and inflammation responses. The present findings provide valuable insights for further exploration of carrots depending on the cultivation method, as a potential dietary source against colon cancer.
Insights
Carrots, particularly those grown with deep sea water minerals (DSWM) fertilizer, inhibit colon cancer in mice by enhancing cell apoptosis and reducing inflammation. This suggests carrots are a promising dietary strategy for cancer prevention.
Area of Science:
- Oncology
- Nutritional Science
- Microbiology
Background:
- Colon cancer remains a significant health concern globally.
- Dietary interventions are crucial for cancer prevention and management.
- Understanding the role of specific foods and cultivation methods in cancer suppression is vital.
Purpose of the Study:
- To investigate the colon cancer-suppressive effects of carrots based on cultivation methods.
- To examine the impact of carrot cultivation on cell apoptosis, inflammation, and metabolites in a mouse model.
- To identify specific carrot types and cultivation techniques with potential anti-cancer properties.
Main Methods:
- Utilized a mouse model of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colon cancer.
- Analyzed carrot effects on apoptosis-related genes (e.g., p53, Caspase 3) and inflammatory markers (e.g., TNF-a, IL-6).
- Performed intestinal microbiota analysis to assess changes in gut bacteria composition.
Main Results:
- Carrots, especially Naturaldream Fertilizer Carrots (NFC) with deep sea water minerals (DSWM), significantly suppressed tumor development.
- DSWM-fertilized carrots increased apoptosis markers and decreased inflammatory factors in colon tissue, serum, spleen, and liver.
- Distinct intestinal microbiota profiles, including Lachnospiraceae and Mucispirillum schaedleri, were observed and associated with anti-tumor effects.
Conclusions:
- Carrots, particularly DSWM-fertilized varieties, demonstrate significant colon cancer inhibitory effects in mice.
- These effects are mediated by the regulation of cell apoptosis and inflammatory responses.
- Cultivation methods significantly influence the anti-cancer potential of carrots, highlighting their role as a dietary strategy.
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