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Plasma protein binding of ritodrine at parturition and in nonpregnant women

A S Gross, K F Brown

    European Journal of Clinical Pharmacology
    |January 1, 1985
    PubMed

    The binding of ritodrine HCl in whole plasma from healthy nonpregnant women, parturients and matched umbilical venous plasma and in solutions of HSA and alpha 1-AGP has been studied by equilibrium dialysis. Binding to plasma from nonpregnant subjects and HSA was independent of ritodrine concentration over a wide range. The free fraction in plasma was high and significantly different between groups of nonpregnant (alpha = 0.64), parturient (alpha = 0.68) and matched umbilical venous plasma (alpha = 0.75). It would seem that variability in transplacental transfer of ritodrine, as a result of plasma binding fluctuations, will be minor.

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