Related Experiment Video
Updated: May 12, 2025
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
9.9K
Segmental Uveoscleral Outflow and its Relationship With Trabecular Outflow in Monkey Eyes
Hoi-Lam Li1, Su Yu1,2, Shan Fan3
1Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States.
Investigative Ophthalmology & Visual Science
|April 28, 2025
Summary
Monkey eyes show segmental uveoscleral outflow, separate from trabecular outflow. This flow occurs in the ciliary stroma and correlates with stromal thickness, offering insights for ocular treatments.
Area of Science:
- Ophthalmology
- Anatomy
- Physiology
Background:
- Segmental trabecular outflow is known in various species.
- Segmental uveoscleral outflow was recently identified in mouse eyes.
- Its presence in other species, like primates, is not well-established.
Purpose of the Study:
- To investigate segmental uveoscleral outflow in monkey eyes.
- To determine the correlation between segmental uveoscleral and trabecular outflow in primates.
Main Methods:
- Aged cynomolgus macaque eyes were used.
- Tracer was injected into the anterior chamber and allowed to diffuse.
- Eyes were sectioned radially, imaged, and analyzed for tracer intensity and stromal thickness.
Main Results:
- Segmental flow patterns were observed in both trabecular and uveoscleral outflow pathways.
- Uveoscleral outflow occurred in ciliary stroma, supraciliary, and suprachoroidal spaces.
- A positive correlation was found between uveoscleral tracer intensity and ciliary stromal thickness.
Conclusions:
- Uveoscleral outflow is segmental and independent of trabecular outflow in monkey eyes.
- Ciliary stromal thickness is a key factor in uveoscleral outflow.
- Findings may guide future ocular device and drug delivery strategies in humans.
Related Concept Videos
01:25Glaucoma: Overview
478
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
478
01:27Open Angle Glaucoma: Treatment
362
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
362
01:28Angle Closure Glaucoma: Treatment
385
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
385