Small brains but big challenges: white matter tractography in early life samples

In the human brain, white matter development is a complex and long-lasting process involving intermingling micro- and macrostructural mechanisms, such as fiber growth, pruning and myelination. Did you know that all these neurodevelopmental changes strongly affect MRI signals, with consequences on tractography performances and reliability? This communication aims to elaborate on these aspects, highlighting the importance of tracking and studying the developing connections with dedicated approaches.