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Functional Seizures-A Critical Comorbidity Overlooked in Epilepsy Research-Reply
Churl-Su Kwon1, Nathalie Jetté2, Charles R Newton3
1Departments of Neurology, Epidemiology, Neurosurgery, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, New York.
JAMA Neurology
|April 28, 2025
Abstract
No abstract available in PubMed .
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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Focal Seizures
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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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