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Updated: May 9, 2025
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Published on: June 16, 2014
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The Cardiovascular-Kidney-Metabolic Health Framework: Implications for Nephrology
Janani Rangaswami1,2, Michael G Shlipak3,4,5, Roy O Mathew6
1Washington DC Veterans Affairs Medical Center, Washington, DC.
Summary
The American Heart Association defined Cardiovascular-Kidney-Metabolic (CKM) syndrome, linking metabolic, kidney, and heart conditions. Nephrologists play a vital role in CKM care, focusing on prevention and early kidney disease intervention for better population health.
Area of Science:
- Cardiology
- Nephrology
- Metabolic Health
Background:
- Cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic risk factors are prevalent and interconnected globally.
- The American Heart Association (AHA) introduced the Cardiovascular-Kidney-Metabolic (CKM) syndrome to address these links.
- CKD is a significant risk factor and mediator for CVD, impacting overall health span.
Purpose of the Study:
- To review the AHA's CKM health initiative for nephrologists.
- To identify nephrologists' roles in multidisciplinary CKM care.
- To explore future nephrology contributions to population-level kidney health.
Main Methods:
- Review of the AHA CKM health initiative framework.
- Analysis of CKD's role within the CKM syndrome.
- Discussion of nephrology's integration into CKM care models.
Main Results:
- The AHA CKM initiative offers a holistic approach to managing interconnected CKM conditions.
- Nephrologists are crucial in prevention, risk prediction, and multidisciplinary CKM care delivery.
- CKD management is central to reducing the global CVD burden.
Conclusions:
- Nephrologists can significantly impact CKM care through early kidney disease screening and intervention.
- Integrating nephrology into CKM care models improves patient outcomes and population health.
- A proactive role for nephrology is essential for advancing kidney health within the CKM framework.
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