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Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Apr 30, 2026

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

Constructing an Olfactometer for Rodent Olfactory Behavior Studies.

Nicole Arevalo¹, M Ryan Mettetal², Francisco Javier Quinones³

¹Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus.

Journal of Visualized Experiments : Jove

|April 28, 2025

Summary

This summary is machine-generated.

Researchers can build a custom olfactometer for mouse olfactory studies, offering a cost-effective and flexible alternative to commercial devices. This DIY approach enhances experimental control and troubleshooting capabilities for olfactory research.

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Area of Science:

Neuroscience
Behavioral Science
Bioengineering

Background:

Olfactometers are essential tools for studying rodent olfactory behavior and brain activity.
Commercial olfactometers can be expensive and difficult to repair, hindering research progress.

Purpose of the Study:

To provide detailed instructions for constructing a custom olfactometer for mouse olfactory behavior experiments.
To offer an open-source, MATLAB-controlled system that enhances research flexibility and reduces costs.

Main Methods:

Detailed parts list and step-by-step construction guide for a custom olfactometer.
MATLAB-based software for user-friendly control and task customization.
Open-source code enabling user modification and adaptation.

Main Results:

Successful construction and implementation of a functional custom olfactometer.
Demonstration of user-friendly control and task customization via MATLAB interface.
Empowerment of researchers with independent design and troubleshooting capabilities.

Conclusions:

Custom olfactometers offer a cost-effective and flexible solution for olfactory research.
DIY olfactometers enhance experimental design, troubleshooting, and overall research robustness.
This approach promotes deeper understanding and independent management of research equipment.