Expression and immunological role of FUNDC2 in pan-cancer
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View abstract on PubMed
Summary
This summary is machine-generated.The mitochondrial protein FUNDC2 shows altered expression in various cancers and may serve as a prognostic biomarker. Its levels correlate with patient survival and immune infiltration, suggesting a role in cancer progression.
Area Of Science
- Oncology
- Molecular Biology
- Bioinformatics
Background
- FUNDC2 (FUNCT domain containing 2) is a novel mitochondrial protein implicated in cancer.
- Its pan-cancer expression patterns, prognostic value, and underlying mechanisms require comprehensive investigation.
Purpose Of The Study
- To investigate the expression, prognostic significance, and potential mechanisms of FUNDC2 in pan-cancer.
- To explore FUNDC2's interactions, phosphorylation, and structural characteristics.
Main Methods
- Utilized TIMER 2.0 for expression and immune infiltration analysis.
- Employed GEPIA for prognosis correlation.
- Applied STRING for protein-protein interactions.
- Predicted phosphorylation and variation sites using cBioPortal and PhosphoNet.
- Predicted FUNDC2 structure with AlphaFold.
Main Results
- FUNDC2 expression significantly differed between cancer and normal tissues, with lower levels observed in 8 cancer types.
- Higher FUNDC2 levels correlated with improved survival in most cancers.
- FUNDC2 expression was linked to B cell immune infiltration.
- Identified potential interacting proteins and 15 phosphorylation sites, including a mutation site at S167.
Conclusions
- FUNDC2 may function as a prognostic biomarker in various cancers.
- Its role in cancer progression might involve modulation of immune infiltration.
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