Related Experiment Video
Updated: May 9, 2025
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Increased Risk of Cardiovascular Diseases in Patients With Chronic Hypoparathyroidism in Sweden
Sigridur Björnsdottir1, Michael Mannstadt2, Bart Clarke3
1Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 Stockholm, Sweden.
Insights
Patients with chronic hypoparathyroidism (hypoPT) face a higher risk of cardiovascular diseases, especially women. This underscores the need for proactive cardiovascular risk management in this population.
Area of Science:
- Endocrinology and Cardiology
- Public Health Research
Background:
- Limited data exists on cardiovascular outcomes in patients with chronic hypoparathyroidism (hypoPT).
- Chronic hypoPT is a condition affecting calcium and phosphate regulation, with potential systemic implications.
Purpose of the Study:
- To investigate the risk of major cardiovascular outcomes in patients diagnosed with chronic hypoPT.
- Specific outcomes examined include myocardial infarction, atrial fibrillation, heart failure, valvular heart disease, peripheral artery disease, and stroke/transient ischemic attack (TIA).
Main Methods:
- A population-based cohort study utilizing Swedish national registries (Patient, Prescribed Drug, Total Population) from 1997-2018.
- Patients with chronic hypoPT were identified and matched with control individuals.
- Statistical analysis adjusted for established cardiovascular risk factors.
Main Results:
- The study included 1,982 patients with chronic hypoPT and 19,499 controls.
- Patients with chronic hypoPT exhibited significantly higher risks for valvular heart disease, peripheral artery disease, heart failure, atrial fibrillation/flutter, acute myocardial infarction, and fatal cardiovascular disease compared to controls.
- Women with chronic hypoPT showed a particularly elevated risk for most cardiovascular outcomes, while men did not present significant differences compared to controls. No significant difference in stroke/TIA risk was observed.
Conclusions:
- Chronic hypoparathyroidism is associated with an increased risk of cardiovascular diseases.
- Women with chronic hypoPT are especially vulnerable to these cardiovascular complications.
- Findings emphasize the critical need for vigilant cardiovascular monitoring and preventive strategies in patients with chronic hypoPT, particularly for women.
Context:
Data on cardiovascular outcomes in patients with chronic hypoparathyroidism (hypoPT) are limited.
Objective:
To investigate the risk of cardiovascular outcomes, acute myocardial infarction, atrial fibrillation/flutter, heart failure, valvular heart disease, peripheral artery disease, and stroke/transient ischemic attack (TIA) in patients with chronic hypoPT.
Design:
The Swedish National Patient Registry, the Swedish Prescribed Drug Registry, and the Total Population Registry, 1997-2018.
Settings:
Population-based cohort study in Sweden.
Patients:
National registries were used to identify patients with chronic hypoPT and matched controls.
Results:
A total of 1982 with chronic hypoPT and 19 499 controls were included. After adjustment for cardiovascular risk factors, patients with chronic hypoPT had higher risk of valvular heart disease [hazard ratio (HR) 2.08; 95% confidence interval (CI) 1.67-2.60], peripheral artery disease (HR 1.78; 95% CI 1.41-2.26), heart failure (HR 1.66; 95% CI 1.44-1.90), atrial fibrillation/flutter (HR 1.58; 95% CI 1.38-1.81), acute myocardial infarction (HR 1.31; 95% CI 1.05-1.64), and fatal cardiovascular disease (HR 1.59; 95% CI 1.40-1.80) compared to matched controls. No significant difference in risk of stroke/TIA was observed. Cardiovascular outcomes did not differ between patients with surgical and nonsurgical chronic hypoPT. Females with hypoPT had a significantly increased risk of valvular heart disease, peripheral artery disease, heart failure, atrial fibrillation, myocardial infarction, and fatal cardiovascular disease compared to female controls. There were no differences in any cardiovascular outcomes between males with hypoPT and male controls.
Conclusion:
The risk of cardiovascular diseases was increased in patients with chronic hypoPT, particularly among women. These findings highlight the need for close monitoring and preventive management of cardiovascular risk factors, especially in women.
More Related Videos
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:14Decreased pulse rate
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
01:18Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...
01:17Increased pulse rate
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...