Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Types of Reports II: Incident or Occurrence Report

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...

Introduction to Documentation and Reporting

Introduction to Documentation and Reporting

Documentation is the systematic process of formally recording, maintaining, and communicating information.
Nursing documentation records essential information and details regarding a patient's care and treatment in written or electronic form. It is a critical aspect of nursing practice that involves documenting assessments, interventions, outcomes, and other relevant details about a patient's health status.
Documentation maps the patient's health journey by creating a comprehensive...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Types of Reports I: Hands-off Report

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:

Nursing Ethical Principles II

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Precision oncology's translation gap-Can molecular tumor boards bridge it?

PLoS medicine·2026

Same journal

Improving suicide prevention in men.

PLoS medicine·2026

Same journal

Multilevel onsite training and mentorship model to accelerate early childhood cancer diagnosis in Northwest Ethiopia: A quasi-experimental mixed method study.

PLoS medicine·2026

Same journal

The well-worn path from armed conflict to measles resurgence.

PLoS medicine·2026

Same journal

Association of armed conflict and global measles cases: A structural equation modeling analysis of 193 countries from 2000 to 2023.

PLoS medicine·2026

Same journal

Cardiovascular outcomes and safety associated with statin therapy for primary prevention in older adults with type 2 diabetes: A target trial emulation study.

PLoS medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 9, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Improving transparency in clinical trial reporting.

Alison Farrell¹,

¹Public Library of Science, San Francisco, California, United States of America.

|April 28, 2025

Summary

This summary is machine-generated.

Transparent reporting of randomized clinical trial design and data is crucial for accurate interpretation and maximum benefit realization in healthcare, policy, and research. Updated CONSORT and SPIRIT guidelines enhance trial quality and outcomes.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

Related Experiment Videos

Last Updated: May 9, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

Area of Science:

Clinical Trials
Research Methodology
Health Policy

Background:

Effective interpretation of randomized clinical trial (RCT) results hinges on transparent reporting of study design, protocol, methods, and analyses.
Lack of clarity in reporting hinders the full realization of findings' benefits for healthcare, policy, and research.
The CONSORT and SPIRIT guidelines are essential for ensuring the quality and reproducibility of clinical trial research.

Purpose of the Study:

To highlight the critical role of transparent reporting in maximizing the impact of randomized clinical trials.
To emphasize the significance of updated CONSORT 2025 and SPIRIT 2025 statements in improving clinical trial quality.
To underscore how clear reporting of trial design and data enhances healthcare, policy, and research outcomes.

Main Methods:

Review of the principles and importance of transparent reporting in clinical trials.
Discussion of the implications of updated CONSORT 2025 and SPIRIT 2025 guidelines.
Analysis of how enhanced transparency influences the interpretation and application of trial findings.

Main Results:

Transparent reporting is fundamental for the accurate interpretation of randomized clinical trial results.
Clarity in reporting ensures that the full potential benefits of trial findings are realized across healthcare, policy, and research domains.
Updated reporting guidelines provide a framework for improving the overall quality and impact of clinical trials.

Conclusions:

The power of randomized clinical trials is significantly amplified by transparent reporting of their design, protocol, methods, and analyses.
Adherence to updated guidelines like CONSORT 2025 and SPIRIT 2025 is vital for advancing medical research and improving patient outcomes.
Enhanced transparency in clinical trial reporting is key to maximizing their value for scientific advancement and public health.