Repigmentation of vitiligo macules treated topically with Efudix cream

Area of Science:

• Dermatology
• Dermatopathology

Background:

• Vitiligo is a chronic skin condition characterized by depigmentation.
• Current treatments for vitiligo have varying efficacy and side effects.

Observation:

• Three patients with symmetrical acral vitiligo experienced repigmentation after topical Efudix cream application.
• Two patients with segmental vitiligo showed no response to the same treatment.

Findings:

• Topical 5-fluorouracil (Efudix) demonstrated efficacy in repigmenting symmetrical vitiligo.
• The treatment was ineffective for segmental vitiligo.
• Histological and electron microscopic analyses characterized the repopulating melanocytes.

Implications:

• Topical 5-fluorouracil may be a potential treatment option for specific types of vitiligo.
• Further research is needed to understand the mechanism of action and optimize treatment protocols.
• Recurrence of vitiligo was noted in one patient, highlighting the need for long-term monitoring.