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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Recommended gentamicin peak plasma levels rarely reached, even with recommended dosages
Quentin Perrier1, Anne-Flore Dumas2, Hélène Pluchart2
1Université Grenoble Alpes, INSERM, LBFA, U1055, Pharmacy Department, Grenoble Alpes University Hospital, Grenoble, France.
Introduction:
The recommended gentamicin peak plasma concentration range is 32-40 mg/L; we aimed to determine how frequently it was reached, and for which gentamicin doses.
Patients And Methods:
We retrospectively reviewed 601 gentamicin peak plasma concentrations in 501 patients aged ≥15 in our institution between 2013 and 2023.
Results:
Median gentamicin dose was 5.9 mg/kg [IQR 4.1-7.9]. Median peak plasma concentration was 16.5 mg/L [IQR 10.8-22.8] and was strongly correlated with dose (p < 0.0001). Only 5.7 % of values were ≥32 mg/L, including 22.8 % for dose ≥10 mg/kg.
Conclusion:
This suggests that existing recommendations regarding either dose or target concentration for gentamicin should be modified.
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