Efficacy and Prognostic Factors of Surgical Resection for Pulmonary Metastases From Ovarian Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Surgical intervention for pulmonary metastases from ovarian cancer can achieve a 5-year survival rate of 69.9%. However, preoperative extrapulmonary metastasis is a significant adverse prognostic factor, requiring careful surgical consideration.
Area Of Science
- Oncology
- Surgical Oncology
- Gynecologic Oncology
Background
- Pulmonary metastases (PMs) from ovarian cancer are rare clinical events.
- The efficacy and prognostic factors of surgical intervention for PMs are not well-established.
Purpose Of The Study
- To validate the efficacy of surgical intervention for pulmonary metastases from ovarian cancer.
- To identify prognostic factors associated with overall survival (OS) after surgery for PMs.
Main Methods
- Retrospective analysis of 48 patients who underwent radical surgery for PMs from ovarian cancer.
- Data collected from the Metastatic Lung Tumor Study Group of Japan (1996-2021).
- Overall survival (OS) was analyzed using multivariable Cox regression.
Main Results
- The 5-year OS rate was 69.9% (95% CI=51.9%-82.2%), with a median survival of 121 months.
- Poorer OS predictors included preoperative extrapulmonary metastasis (HR=5.354), elevated tumor markers (HR=2.999), and disease-free interval < 24 months (HR=4.355).
- Preoperative extrapulmonary metastasis was an independent adverse prognostic factor (HR=6.229).
Conclusions
- Surgical resection of PMs from ovarian cancer can yield favorable long-term survival.
- Preoperative extrapulmonary metastasis is a critical adverse prognostic factor.
- Careful patient selection and consideration of surgical indications are essential.
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