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Cryptococcus albidus meningitis: A case report and literature review

Genzhu Wang1, Hang Liu, Xiaoying Wang

  • 1Beijing Electric Power Hospital of State Grid Co. of China, Capital Medical University Electric Teaching Hospital, Beijing, China.

Medicine
|April 28, 2025
PubMed
Abstract

Insights

Central nervous system infections from Cryptococcus albidus are rare but dangerous. This study highlights using ideal body weight for liposomal-amphotericin B dosing in obese patients with C. albidus meningitis, ensuring safe and effective treatment.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Pharmacology

Background:

  • Central nervous system (CNS) infections caused by Cryptococcus albidus are rare and associated with high mortality.
  • Limited clinical data exists on the optimal use of liposomal-amphotericin B (liposomal-AmB) for cryptococcal meningitis.

Purpose of the Study:

  • To report the first case of successful liposomal-AmB treatment for C. albidus meningitis in a severely obese patient.
  • To evaluate the efficacy and safety of using ideal body weight for liposomal-AmB dosing in this patient population.
  • To review existing literature on CNS infections caused by C. albidus and related species.

Main Methods:

  • A severely obese female patient presented with intracranial lesions and headache.
  • C. albidus was isolated from cerebrospinal fluid after glioma resection.
  • Treatment involved liposomal-AmB (50 mg/day IV) and 5-fluorocytosine (10 g/day PO) for 6 weeks.

Main Results:

  • The patient's Cryptococcus species infection was confirmed via cerebrospinal fluid culture and mass spectrometry.
  • The patient received liposomal-AmB and 5-fluorocytosine for 6 weeks.
  • The patient was asymptomatic upon discharge, indicating successful treatment.

Conclusions:

  • CNS infections due to C. albidus are uncommon.
  • Calculating liposomal-AmB dosage based on ideal body weight is a recommended approach for severely obese patients with C. albidus meningitis.
Keywords:
case reportcentral nervous system infectioncryptococcal meningitisliposomal-amphotericin Breview

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