Related Experiment Video
Updated: Jun 15, 2026
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Treatment of Primary Solid Renal Tumours Using Histotripsy: Study Protocol for the CAIN Feasibility Trial
Tze Min Wah1, Joseph F Amaral2, Paul F Laeseke3,4
1Diagnostic and Interventional Radiology, Leeds Teaching Hospitals Trust and Leeds Institute of Medical Research, University of Leeds, Leeds, West Yorkshire, UK. tze.wah@nhs.net.
Purpose:
The purpose of this prospective, multi-centre, single-arm feasibility trial is to evaluate the technical success and safety profile of the HistoSonics System for the treatment of primary solid renal tumours using histotripsy.
Methods/Design:
The CAIN trial will enrol up to 20 patients with a non-metastatic solid renal tumour ≤ 3 cm treated with histotripsy. Histotripsy is a non-thermal and non-ionizing mechanical process of tissue destruction resulting from the targeted delivery of focused ultrasound pulses. The primary endpoints are technical success and freedom from index procedure related major complications. Technical success is defined as complete coverage of the tumour as determined ≤ 36 h post-index procedure by contrast-enhanced magnetic resonance imaging (MRI) or computerized tomography (CT). An index procedure related major complication is defined as Clavien-Dindo Classification Grade 3 or higher up to 30 days after the last histotripsy procedure. Treated patients will have a follow-up visit performed at 14 days, 30 days, 90 days, and 180 days post-procedure.
Trial Registration:
Clinicaltrials.gov identifier NCT05432232 & NIHR CRN CPMS 53429.
More Related Videos
08:54Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
05:56Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
Published on: January 9, 2019
