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Updated: May 9, 2025

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Strange relatives: the enigmatic arbo-jingmenviruses and orthoflaviviruses
Edwin O Ogola1, Amitava Roy2,3, Kurt Wollenberg3
1Biology of Vector Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th Street, Hamilton, MT, 59840, USA. edwin.ogola@nih.gov.
Abstract:
Arthropod - and vertebrate-associated jingmenviruses (arbo-JMV) have segmented positive-strand RNA genomes and are provisional members of the genus Orthoflavivirus (family Flaviviridae). Current investigations have described arbo-JMV infection in vertebrate hosts in proximity to humans. This raises concerns about the virus host range and public health implications. This review explores the genomic and evolutionary relationship between arbo-JMV and orthoflaviviruses and evaluates the potential of arbo-JMV to pose a public health threat.
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