Association of non-insulin-based insulin resistance indices, mean platelet volume and prostate cancer: a cross-sectional study
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View abstract on PubMed
Summary
This summary is machine-generated.Non-insulin-based insulin resistance (NI-IR) indices are linked to higher prostate cancer (PCa) risk. The interaction between mean platelet volume (MPV) and insulin resistance may further elevate PCa risk.
Area Of Science
- Endocrinology
- Oncology
- Cardiovascular Health
Background
- The association between insulin resistance and prostate cancer (PCa) remains debated.
- Limited research has explored various non-insulin-based insulin resistance (NI-IR) indices and mean platelet volume (MPV) in relation to PCa.
Purpose Of The Study
- To investigate the association between multiple NI-IR indices and PCa risk.
- To examine the potential interaction between insulin resistance and MPV in influencing PCa risk.
Main Methods
- Cross-sectional study with 354 PCa cases and 1,498 controls.
- Inverse probability weighting and weighted logistic regression to assess NI-IR indices and PCa risk.
- Restricted cubic spline plots and generalized additive models to analyze trends and interactions.
Main Results
- All evaluated NI-IR indices (ZJU, TyG, TG/HDL-c, METS-IR) were significantly associated with increased PCa risk.
- Higher categories of NI-IR indices showed substantially elevated odds ratios for PCa.
- An interaction between TG/HDL-c and MPV indicated that increased TG/HDL-c and decreased MPV were associated with progressively higher PCa risk.
Conclusions
- NI-IR indices are independently associated with an elevated risk of prostate cancer.
- The interplay between insulin resistance markers and MPV may play a role in PCa development.
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