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Summary
Hyperviscosity syndrome in Waldenström macroglobulinemia is often identified by measuring relative serum viscosity. Whole blood viscosity is crucial for patients with central nervous system symptoms and low serum viscosity.
Area of Science:
- Hematology
- Oncology
- Clinical Pathology
Background:
- Waldenström macroglobulinemia is a rare lymphoproliferative disorder.
- Hyperviscosity syndrome can complicate Waldenström macroglobulinemia, leading to various clinical manifestations.
Purpose of the Study:
- To determine the correlation between blood viscosity and hyperviscosity syndrome symptoms in Waldenström macroglobulinemia patients.
- To identify specific viscosity thresholds indicative of symptomatic hyperviscosity.
Main Methods:
- Patients with Waldenström macroglobulinemia were assessed for hyperviscosity syndrome.
- Relative serum viscosity and calculated whole blood viscosity were measured.
- Correlation analysis was performed between viscosity measurements and clinical symptoms.
Main Results:
- The majority of symptomatic patients exhibited whole blood viscosity above 8.0 centipoises.
- A direct correlation (r = 0.75) was observed between whole blood viscosity and relative serum viscosity.
- One patient with neurological symptoms had high whole blood viscosity but low serum viscosity.
Conclusions:
- Relative serum viscosity measurement is effective in identifying most patients with hyperviscosity syndrome.
- Whole blood viscosity determination is recommended for patients with central nervous system findings and low serum viscosity.