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Updated: May 9, 2025

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Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
Published on: September 13, 2024
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Snoring as a Possible Protective Factor for Temporomandibular Joint Disorders
1The First Hospital of Jilin University, Changchun, Jilin Province, China.
Journal of Oral Rehabilitation
|April 28, 2025
Summary
Snoring may reduce the risk of developing temporomandibular joint disorders (TMD), according to genetic evidence. This study found no evidence that TMD increases the likelihood of snoring.
Area of Science:
- Genetics
- Epidemiology
- Sleep Science
Background:
- Sleep quality is linked to temporomandibular joint disorders (TMD).
- The role of snoring in this association requires clarification.
- Directionality of the snoring-TMD relationship is debated.
Purpose of the Study:
- To investigate the causal relationship between snoring and TMD.
- To determine if snoring influences TMD risk.
- To assess if TMD influences snoring.
Main Methods:
- Two-sample Mendelian randomization (MR) analysis.
- Utilized large-scale genome-wide association study (GWAS) data.
- Employed various statistical methods including IVW and MR-Egger regression.
Main Results:
- Genetic predisposition to snoring was associated with a reduced risk of TMD (OR=0.156, p=0.0309).
- No significant association was found for TMD influencing snoring susceptibility (p=0.1926).
- Sensitivity analyses indicated no significant pleiotropy.
Conclusions:
- Provides novel genetic evidence for a potential causal link between snoring and decreased TMD risk.
- Does not support a causal effect of TMD on snoring.
- Highlights the importance of considering snoring in TMD research.
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