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Deferring blood donors with out-of-range blood pressure: Does it decrease the risk of adverse reactions?
Catherine Thibeault1, Antoine Lewin1, Isabelle Rabusseau2
1Medical Affairs and Innovation, Héma-Québec, Montréal, Québec City, Canada.
Transfusion
|April 29, 2025
Summary
Blood donation blood pressure (BP) deferrals are not associated with vasovagal reactions (VVR). Withdrawing BP deferrals did not increase VVR incidence, supporting their removal for blood donors.
Area of Science:
- Hematology
- Cardiovascular Medicine
- Public Health
Background:
- Blood services frequently defer donors with out-of-range blood pressure (BP) readings.
- Evidence supporting BP deferral practices is equivocal.
- Vasovagal reactions (VVR) are a common concern in blood donation.
Purpose of the Study:
- To assess the association between pre-donation BP and VVR in blood donors.
- To compare VVR rates before and after the withdrawal of BP deferrals.
Main Methods:
- Analysis of 532,042 donations from 189,329 donors in Québec, Canada.
- Comparison of VVR rates during a pre-pandemic period (BP deferral) and a late-pandemic period (no BP deferral).
- Statistical adjustment for age, sex, and donor status.
Main Results:
- No significant association was found between low or high pre-donation BP and the odds of VVR.
- The odds ratio for VVR in donors with low BP was 1.03 (95% CI: 0.67-1.63).
- The odds ratio for VVR in donors with high BP was 0.96 (95% CI: 0.81-1.14).
- The VVR rate remained stable at approximately 3.0-3.1% in both periods.
Conclusions:
- Pre-donation blood pressure levels are not associated with vasovagal reactions.
- Withdrawing BP deferral criteria did not lead to an increase in VVR incidence.
- The findings provide strong evidence to support the discontinuation of BP deferrals in blood donation practices.
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