Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Effective Breast Cancer Therapy and Enhanced Wound...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Oncology

Background:

• Surgical resection is the primary treatment for triple-negative breast cancer (TNBC).
• Post-operative complications like tumor recurrence and infections impede recovery.
• Novel strategies are needed to improve outcomes after TNBC surgery.

Purpose of the Study:

• To develop a multifunctional bioactive dual-layered nanofibrous matrix (MBDL-NanoMat) for post-surgical TNBC care.
• To integrate multiple therapeutic modalities for enhanced anti-cancer and wound healing effects.
• To address challenges of tumor recurrence and infection in TNBC treatment.

Main Methods:

• Fabrication of a dual-layered nanofibrous matrix with hydrophilic (HyPhil) and hydrophobic (HyPhob) components.
• Incorporation of copper peroxide nanoparticles (Cu NPs) in the HyPhil layer for chemodynamic therapy (CDT), ferroptosis, cuproptosis, and antibacterial action.
• Integration of rapamycin in the HyPhob layer for sustained chemotherapy (CT) and antibacterial activity, enhanced by near-infrared laser irradiation for photothermal therapy (PTT).

Main Results:

• The MBDL-NanoMat demonstrated synergistic therapeutic effects by combining CT, CDT, PTT, ferroptosis, and cuproptosis.
• The matrix successfully suppressed tumor recurrence and accelerated wound healing in preclinical models.
• Enhanced angiogenesis, collagen deposition, and dermal regeneration were observed without systemic toxicity.

Conclusions:

• The MBDL-NanoMat platform offers a promising solution for post-surgical TNBC management.
• This innovative material simultaneously targets tumor recurrence and promotes wound healing.
• Further research holds potential for significant advancements in oncological and regenerative medicine.