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Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Osteoclastogenesis-characterized osteoinductive biphasic calcium phosphate ceramic for bone regeneration in rabbit
1Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401120, P. R. China. jiping@hospital.cqmu.edu.cn.
Abstract:
Calcium phosphate ceramics can be osteoinductive. Osteoinductive calcium phosphate ceramics are attractive bone substitutes because of their ability to induce bone formation in soft tissues far from osseous sites. Herein, we introduce an osteoinductive biphasic calcium phosphate (BCP) ceramic for maxillary sinus lift. Compared to protein-deprived bovine bone mineral (DBBM), BCP supported osteoclastogenesis in vitro and in vivo, induced bone formation following intramuscular implantation in FVB/NCrl (FVB) mice, and enhanced bone regeneration in the rabbit maxillary sinus lift. Our findings indicate that BCP is a promising bone substitute for bone regeneration in maxillary sinus lifts. Furthermore, the current information makes optimizing bone substitutes more convenient and effective. For instance, in vitro osteoclastogenesis evaluation of biomaterials can be used as the first screening, bone formation following non-osseous implantation as the follow-up and bone regeneration in pre-clinical bone defects as the final confirmation.
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