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Surgery for chronic pancreatitis across Europe (ESCOPA): prospective multicentre study
Charlotte L van Veldhuisen1,2,3, Charlotte A Leseman1,2, Fleur E M De Rijk2,4
1Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
The British Journal of Surgery
|April 29, 2025
Summary
Surgery for symptomatic chronic pancreatitis in Europe demonstrated good pain relief and improved quality of life with low morbidity. Multidisciplinary consultation is recommended for all patients before intervention.
Area of Science:
- Gastroenterology
- Surgical Gastroenterology
- Pancreatology
Background:
- Randomized trials indicate surgery is superior to endoscopy for symptomatic chronic pancreatitis.
- Large international studies quantifying surgical impact are lacking.
- This study evaluates European practice in chronic pancreatitis surgery.
Purpose of the Study:
- To assess indications for surgery in chronic pancreatitis.
- To analyze surgical techniques used across Europe.
- To evaluate the outcomes of chronic pancreatitis surgery.
Main Methods:
- Prospective multicenter study of 207 patients across 13 European countries.
- Data collected on surgical procedures, pain scores (Izbicki), and quality of life (PANQOLI, SF-12).
- Analysis of predictors for pain relief at 6-month follow-up.
Main Results:
- Surgery for chronic pancreatitis had 14.0% major morbidity and 1.4% 90-day mortality.
- In 113 patients operated on for pain, 72.6% achieved pain relief (complete or partial).
- Significant improvements in quality of life scores (PANQOLI, SF-12) were observed.
Conclusions:
- Surgery for chronic pancreatitis in Europe is associated with low morbidity.
- Patients experience significant pain relief and improved quality of life post-surgery.
- Multidisciplinary consultation is recommended prior to any intervention for chronic pancreatitis.
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