Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Spinal Cord01:54

The Spinal Cord

29.0K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
29.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication of Tissue Constructs and Organoids Using Electrospun Micro/Nanofibers.

Chemical reviews·2026
Same author

Bridging the gap: gradient scaffolds as bioinstructive platforms for peripheral nerve repair.

Chemical Society reviews·2026
Same author

Nanofiber-Based Electroactive Interfaces Enabling Coordinated Neuromodulation and Peripheral Nerve Regeneration.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models.

Science advances·2025
Same author

Electrically Conductive Hydrogels for Wound Healing.

Advances in wound care·2025
Same author

Rational Fabrication of Functionally-Graded Surfaces for Biological and Biomedical Applications.

Accounts of materials research·2025

Related Experiment Video

Updated: May 9, 2025

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

6.9K

Nanofibrous Guidance Conduits with Multiple Gradient Cues for Spinal Cord Repair.

Xindan Zhang1,2, Wen Guo3, Jiangang Zhang3

  • 1Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|April 29, 2025
PubMed
Summary

Novel guidance conduits featuring multiple gradient cues promote spinal cord repair. This biomimetic scaffold enhances neural regeneration and functional recovery after spinal cord injury (SCI) in rats.

Keywords:
collagen particlesdensity gradientnanofibrous nerve guidance conduitneurotrophin‐3 releasespinal cord injury repair

More Related Videos

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.2K
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.3K

Related Experiment Videos

Last Updated: May 9, 2025

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

6.9K
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.2K
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.3K

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Regenerative Medicine

Background:

  • Spinal cord injury (SCI) causes severe disability and lacks effective treatments for neurological recovery.
  • Current therapies mainly manage symptoms, with limited success in restoring function.

Purpose of the Study:

  • To design and fabricate novel guidance conduits with integrated multiple gradient cues for enhanced spinal cord repair.
  • To investigate the efficacy of these conduits in promoting neural regeneration and functional recovery in a rat model.

Main Methods:

  • Fabrication of guidance conduits using electrospinning and masked coaxial electrospraying.
  • Integration of topological, haptotactic, and chemotactic cues into a single scaffold.
  • Assessment of conduit effects on cell migration, neural stem cell differentiation, axonal extension, and functional recovery in a rat SCI model.
  • Single-nucleus RNA sequencing to analyze cellular responses and tissue regeneration.

Main Results:

  • The multi-cue guidance conduit significantly promoted cell migration, neural stem cell differentiation, and axonal extension.
  • Substantial improvements in spinal cord regeneration and functional recovery were observed in the rat model.
  • Single-nucleus RNA sequencing revealed inhibition of fibroblast proliferation, preserved microglial homeostasis, and facilitated regeneration of neural structures and synapses.

Conclusions:

  • The developed guidance conduit is a versatile platform for fabricating tissue scaffolds with multiple gradient cues.
  • This innovative approach offers a promising strategy for spinal cord injury treatment and broader tissue regeneration applications.