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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photocatalytic oxidation of biologically relevant reducing agents by [Ru(bpy)3](PF6)2
Iman Doumi1, Daniella Al Othman1, Shao-An Hua2,3
1Institut de Chimie (UMR 7177) University of Strasbourg - CNRS4 rue Blaise Pascal, 67000 Strasbourg, France. pfaller@unistra.fr.
Abstract:
Ru complexes are widely studied in photodynamic therapy. The type I mechanism of action is based on a photoinduced electron transfer from the complex to O2 and needs an electron donor to be catalytic. Little is known about electron donors among physiologically relevant compounds. Hence, we investigated the oxidation of ascorbate, NADH, cysteine, and glutathione with the canonical [Ru(bpy)3](PF6)2 as well as a derivative with a peripheral disulphide unit, [Ru(S-Sbpy)(bpy)2](PF6)2. The established reactivity order is ascorbate > NADH ∼ cysteine > glutathione.
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