Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.

International journal of molecular sciences·2025

Same author

The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity.

Journal of personalized medicine·2024

Same author

Bilateral renal lymphangiectasia: Literature review of a rare entity.

Saudi medical journal·2024

Same author

Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study.

Journal of personalized medicine·2022

Search research articles

Related Experiment Video

Updated: May 9, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Natural Products as Modulators of miRNA in Hepatocellular Carcinoma: A Therapeutic Perspective.

Shahzada Khalid Sohail¹

¹Department of Pathology, College of Medicine, University of Bisha, Bisha, Saudi Arabia.

The Journal of Gene Medicine

|April 29, 2025

Summary

Hepatocellular carcinoma (HCC) research explores microRNAs (miRNAs) as diagnostic and prognostic biomarkers. Natural compounds show promise in modulating miRNAs for novel HCC therapies.

Keywords:

diagnosis hepatocellular carcinoma natural products oncogenic miRNAs pathogenesis tumor suppressor miRNAs

More Related Videos

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Related Experiment Videos

Last Updated: May 9, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Hepatocellular carcinoma (HCC) presents a significant global health challenge with high mortality and limited treatment options.
Natural compounds are increasingly recognized for their therapeutic potential in cancer management.
MicroRNAs (miRNAs) play crucial roles in cancer development and progression.

Purpose of the Study:

To review the diagnostic and prognostic value of miRNAs as biomarkers in HCC.
To explore the therapeutic potential of natural products in modulating miRNA expression for HCC treatment.
To highlight the dual role of miRNAs in HCC pathogenesis and as therapeutic targets.

Main Methods:

Literature review of recent studies on miRNAs and natural compounds in HCC.
Analysis of the regulatory functions of specific miRNAs (e.g., miR-21, miR-34a, miR-203, miR-16, miR-483-3p) in HCC pathogenesis.
Examination of evidence for natural products in modulating miRNA expression and their synergistic effects.

Main Results:

Specific miRNAs (miR-21, miR-483-3p) are implicated as oncogenic factors promoting HCC.
Other miRNAs (miR-34a, miR-203, miR-16) show potential as tumor suppressors, prognostic markers, or diagnostic tools.
Natural compounds, including phytochemicals, demonstrate the ability to modulate miRNA expression and may enhance conventional therapies.

Conclusions:

miRNAs are critical regulators of HCC development and progression, serving as valuable biomarkers.
Natural products offer a promising avenue for HCC therapy by targeting miRNA pathways.
Integrating miRNA-based diagnostics and therapeutics, potentially with natural compounds, could improve HCC management.