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Updated: May 9, 2025
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Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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Organoid models in bladder cancer: From bench to bedside?
Hongda Zhao1,2, Vincy Wing Sze Ho1,2, Kang Liu1,2
1S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Bladder Cancer (Amsterdam, Netherlands)
|April 29, 2025
Summary
Patient-derived organoids offer a promising avenue for advancing bladder cancer (BC) research and treatment. These models show potential for precision diagnosis and drug screening, overcoming limitations of traditional preclinical models.
Area of Science:
- Urological Oncology
- Cancer Research
- Biotechnology
Background:
- Bladder cancer (BC) is a prevalent and aggressive malignancy with significant diagnostic and therapeutic challenges.
- Patient-derived organoids (PDOs) represent a novel approach for precision diagnosis and treatment of BC.
- Traditional preclinical models struggle to accurately mimic the complexity of human tumors.
Purpose of the Study:
- To provide a comprehensive summary of current bladder cancer organoid studies.
- To highlight the applications of organoid models in basic research, clinical translation, and therapeutic discovery for BC.
- To assess the potential of organoids in personalized medicine for bladder cancer.
Main Methods:
- A comprehensive literature search was conducted on bladder cancer organoid research.
- The review focused on the current state of organoid models and their applications.
- Analysis included genetic fidelity, drug screening capabilities, and limitations.
Main Results:
- Organoid models offer genetic fidelity and high-throughput drug screening capabilities for BC.
- Challenges include limited tumor microenvironment representation and technical complexity.
- Future directions involve integrating immunotherapy, co-culture systems, and organoid-on-chip technologies.
Conclusions:
- Organoid technology presents a groundbreaking tool for studying BC biology, genetic alterations, and drug responses.
- Organoids facilitate advancements in personalized medicine for bladder cancer.
- Further development is needed to overcome limitations and enhance clinical applicability.
