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Updated: May 9, 2025
06:35
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
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Research progress on cancer-associated fibroblasts in osteosarcoma
Liwen Feng1,2, Yuting Chen3, Wenyi Jin4
1Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Oncology Research
|April 29, 2025
Summary
Cancer-associated fibroblasts (CAFs) play a crucial role in osteosarcoma (OS) progression by influencing tumor cell signaling, invasion, and immune response. Understanding CAFs offers new therapeutic avenues for this bone cancer.
Area of Science:
- Oncology
- Cancer Biology
- Fibroblast Research
Background:
- Osteosarcoma (OS) is a primary bone cancer with limited therapeutic options.
- Cancer-associated fibroblasts (CAFs) are key players in tumor microenvironments but their role in OS is not well-defined.
Purpose of the Study:
- To review the current understanding of CAFs in osteosarcoma pathogenesis.
- To explore the cellular origin, classification, and functions of CAFs in OS.
Main Methods:
- Literature review focusing on CAFs in osteosarcoma and other cancers.
- Synthesis of existing research on CAF mechanisms and their impact on tumor progression.
Main Results:
- CAFs significantly influence OS cell signaling, proliferation, invasion, metastasis, epithelial-mesenchymal transition, stemness, angiogenesis, and immune modulation.
- CAFs are implicated in various aspects of tumor development and progression in OS.
Conclusions:
- CAFs represent a promising target for novel osteosarcoma therapies.
- Targeting CAF activation, CAF-derived factors, or depleting CAFs may offer effective treatment strategies for OS.
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