Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application

Area of Science:

• Biomedical science
• Gas therapy
• Molecular medicine

Background:

• Molecular hydrogen (H₂) is the smallest gas molecule, offering high bioavailability and cellular penetration.
• H₂ is recognized for its therapeutic potential in treating diverse diseases.
• Understanding H₂'s delivery and action mechanisms is vital for advancing hydrogen medicine.

Purpose of the Study:

• To review H₂'s mechanisms of action and administration methods.
• To explore H₂'s application in treating intestinal diseases and other conditions.
• To discuss challenges and solutions for clinical H₂ application.

Main Methods:

• Literature review of H₂ mechanisms, administration, and therapeutic applications.
• Analysis of H₂'s role in inflammatory bowel disease, ischemia-reperfusion, and colorectal cancer.
• Exploration of nanoplatforms and gut microbiota interactions for H₂ delivery.

Main Results:

• H₂ exhibits therapeutic efficacy influenced by administration, duration, and concentration.
• Nanoplatforms show promise for overcoming H₂ delivery challenges.
• Gut microbiota interactions may elucidate H₂'s intestinal disease mechanisms.

Conclusions:

• H₂ holds significant therapeutic potential, particularly for intestinal diseases.
• Nanotechnology and understanding gut microbiota are key to optimizing H₂ therapy.
• Future research should focus on synergistic effects and personalized treatment plans for precision medicine.