Related Experiment Video
Updated: May 9, 2025

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
Published on: January 7, 2019
Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from
1School of Public Health, Wuhan University, Wuhan, China.
Introduction:
Although previous researches have suggested that certain dietary nutrients, such as carotenoids, have an effect on depression, epidemiological evidence on the relationship between lycopene and depression remains limited. This study aimed to investigate the association between dietary lycopene intake and depression risk in American adults.
Methods:
Data from 18,664 participants in the National Health and Nutrition Examination Survey (NHANES, 2007-2016) were analyzed, with depression defined by a nine-item Patient Health Questionnaire (PHQ-9) score ≥ 10. Dietary lycopene intake was estimated from the mean of two 24-h dietary recalls. Binary logistic regression and restricted cubic spline (RCS) models were employed to assess the relationship.
Results:
Depression prevalence was 8.98%, and adjusted analyses indicated that higher dietary lycopene intake was significantly associated with a reduced depression risk compared to the lowest quartile (ORs for the second, third, and fourth quartiles: 0.851 [95% CI, 0.737-0.982], 0.829 [95% CI, 0.716-0.960], and 0.807 [95% CI, 0.695-0.938], respectively). Additionally, a U-shaped relationship was observed, with a reduction in depression risk associated with dietary lycopene intake ranging from 0 to 10,072 μg/d (P-non-linear = 0.017).
Discussion:
This study suggested that higher dietary lycopene intake may confer a protective effect against depression in American adults.
More Related Videos
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
07:05Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
Related Concept Videos
Cancer Prevention
Some...
Longitudinal Research
Psychoneuroimmunology: Diabetes and Cancer
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview