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Correlation between hepatic blood flow and coagulation indices in chronic active hepatitis and liver cirrhosis
Insights
Hepatic blood flow (HBF) in liver cirrhosis (LC) patients correlated with liver protein synthesis markers, unlike in chronic active hepatitis (CAH). This suggests HBF reflects residual liver cell mass in LC.
Area of Science:
- Hepatology
- Clinical Biochemistry
Background:
- Hepatic blood flow (HBF) is proposed to correlate with liver cell mass.
- Chronic active hepatitis (CAH) and liver cirrhosis (LC) are distinct liver conditions affecting liver function.
Purpose of the Study:
- To investigate the relationship between HBF and liver protein synthesis markers in patients with CAH and LC.
- To determine if HBF can serve as an indicator of residual liver cell mass in these conditions.
Main Methods:
- Studied HBF in 21 CAH patients and 20 LC patients.
- Correlated HBF with serum albumin, Normotest, antithrombin III, prekallikrein, alpha 2-antiplasmin, and plasminogen levels.
Main Results:
- No significant correlation was found between HBF and protein synthesis markers in CAH patients.
- HBF showed a significant correlation with all examined protein synthesis markers in LC patients.
Conclusions:
- HBF does not reflect liver cell mass in CAH.
- In LC, HBF correlates with markers of liver protein synthesis, indicating its potential to reflect residual liver cell mass.
Abstract:
Hepatic blood flow (HBF) has been reported to reflect liver cell mass. HBF was studied in 21 patients with chronic active hepatitis (CAH) and in 20 patients with liver cirrhosis (LC). It was correlated with such indices of liver protein synthesis as serum albumin, Normotest, plasma activity of antithrombin III, prekallikrein, alpha 2-antiplasmin and plasminogen. No correlation between HBF and the examined parameters was seen in CAH. HBF correlated with all the indices of liver protein synthesis in LC, thus suggesting that serum albumin, antithrombin III, Normotest, prekallikrein, plasminogen, and alpha 2-antiplasmin could reflect the residual liver cell mass in LC.