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Updated: Jul 25, 2026

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Cone Beam Intraoperative Computed Tomography-based Image Guidance for Minimally Invasive Transforaminal Interbody Fusion
Published on: August 6, 2019
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Long-Term Outcomes of Minimally Invasive vs. Traditional Open Spinal Fusion: A Comparative Analysis
Bahram Saber1, Devendra K Agrawal1
1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Summary
Minimally invasive spinal fusion (MISF) offers reduced trauma and faster recovery compared to open surgery. Long-term outcomes are similar, but more research is needed on adjacent segment disease and cost-effectiveness.
Area of Science:
- Orthopedic Surgery
- Neurosurgery
- Spinal Disorders
Background:
- Spinal fusion is a common procedure for spinal conditions.
- Open spinal fusion is the traditional method.
- Minimally invasive spinal fusion (MISF) is an alternative aiming for reduced trauma and faster recovery.
Purpose of the Study:
- To compare long-term outcomes of MISF versus traditional open spinal fusion.
- To evaluate perioperative results, pain relief, functional recovery, fusion rates, and cost-effectiveness.
- To identify research gaps and future directions in MISF.
Main Methods:
- Systematic literature review and critical examination of existing studies.
- Comparison of perioperative data, long-term clinical outcomes, and cost-effectiveness analyses.
- Focus on fusion rates, complication risks, and adjacent segment disease (ASD).
Main Results:
- MISF shows reduced blood loss, shorter hospital stays, and lower infection rates, but potentially longer surgical times and a steeper learning curve.
- Long-term clinical outcomes, including fusion rates and improvements in pain and function, appear comparable between MISF and open fusion.
- The impact of MISF on adjacent segment disease is inconclusive; cost-effectiveness may favor MISF in the long term.
Conclusions:
- MISF is a viable alternative to open spinal fusion with comparable long-term results.
- Further high-quality, long-term randomized controlled trials are necessary to address current research limitations.
- Optimizing surgical decision-making and patient outcomes requires further investigation into MISF's long-term effects and biomechanics.
Keywords:
Adjacent Segment Disease (ASD)Cost-Effectiveness in Spine SurgeryFusion Success RatesHealthcare Utilization in Spine SurgeryLateral lumbar interbody fusionLong-Term Spine Surgery OutcomesMISF vs. Open TLIFMinimally Invasive Spinal Fusion (MISF)Open Spinal FusionPain Relief in Spinal FusionPerioperative ComplicationsPostoperative RecoverySpinal Degenerative Disease TreatmentSpinal InstrumentationSpinal Surgery OutcomesSurgical BiomechanicsTraditional open spinal fusionTransforaminal lumbar interbody fusion (TLIF)
