Multidomain intervention for delaying aging in community-dwelling older adults (MIDA): study design and protocol

Area of Science:

• Gerontology
• Preventive Medicine
• Biogerontology

Background:

• Healthy aging is a growing research area focused on interventions to delay aging processes.
• Multidomain interventions targeting functional ability show promise for older adults.
• Limited research exists on multidomain interventions involving cognition, exercise, and nutrition for aging delay.

Purpose of the Study:

• To explore the effects of a novel multidomain intervention on delaying aging in community-dwelling older adults.
• To introduce a new strategy for aging delay and provide a practical approach for healthcare.
• To assess the impact of cognitive training, exercise, and nutritional guidance on aging.

Main Methods:

• A 6-month Zelen-design randomized controlled trial (Multidomain Intervention for Delaying Aging in Community-dwelling Older Adults - MIDA).
• 248 participants aged 60-85 randomized to intervention or control groups, with 12-month follow-up.
• Intervention includes cognitive training, exercise, and nutritional guidance via group and family sessions.

Main Results:

• Primary outcome: change in epigenetic age acceleration and pace of aging.
• Secondary outcomes: changes in frailty score and intrinsic capacity.
• Other outcomes: physical function, body composition, aging biomarkers, inflammation, blood parameters, and lifestyle.

Conclusions:

• The study will evaluate a multidomain intervention's efficacy in delaying aging.
• Findings aim to offer a practical, evidence-based strategy for healthcare institutions.
• This research contributes to the growing field of healthy aging interventions.