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Updated: May 9, 2025
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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
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Genetic Evolution Between HIV-1 Groups M and O: HIV-1/MO Recombinant Forms.
Moisan Alice1, Tombette Fabienne1, Plantier Jean-Christophe1
1Univ Rouen Normandie, Université de Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, CHU Rouen, Department of Virology, National Reference Center of HIV, Rouen, France.
Journal of Medical Virology
|April 29, 2025
Summary
HIV-1/M and HIV-1/O variants recombine to form unique recombinant forms (URF_MO). This review explores their characteristics, emergence, and impact on HIV diagnosis, treatment, and replication.
Area of Science:
- Virology
- Genetics
- Molecular Biology
Background:
- Human Immunodeficiency Virus (HIV) displays significant genetic diversity.
- Genetic recombination is a key evolutionary mechanism in HIV.
- Co-circulation of HIV-1/M and HIV-1/O variants has led to documented dual infections.
Purpose of the Study:
- To review current knowledge on HIV-1/MO recombinant forms.
- To analyze their virological and genetic characteristics, phylogenetic profiles, and breakpoints.
- To assess the impact of HIV-1/MO recombination on diagnosis, monitoring, treatment, and replicative capacity.
Main Methods:
- Literature review of HIV-1/MO dual infections and recombinant forms.
- Analysis of genetic characteristics, including phylogenetic relationships and genome profiles.
- Examination of breakpoint locations and their potential functional significance.
Main Results:
- Twenty unique HIV-1/MO recombinant forms (URF_MO) have been described.
- These recombinants exhibit greater diversity and complexity than initially anticipated.
- Recombination between HIV-1/M and HIV-1/O variants leads to novel intergroup forms.
Conclusions:
- HIV-1/MO recombinants present unique virological and genetic properties.
- Understanding their emergence and characteristics is crucial for diagnostics and therapeutics.
- Further research is needed to explore the emergence and virological implications of these complex recombinants.
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