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Updated: May 11, 2026

Visualisation and Quantification of Intracellular Interactions of Neisseria meningitidis and Human α-actinin by Confocal Imaging
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Complete genome sequence of a Neisseria meningitidis isolate from an ankle joint with septic arthritis

Eduardo Rubio-Mora1, María Amoroto-Bengoetxea1, Alicia Rico Nieto1,2,3

  • 1Servicio de Microbiología y Parasitología. Hospital Universitario La Paz, Madrid, Spain.

Microbiology Resource Announcements
|April 29, 2025
PubMed

Insights

The complete genome of *Neisseria meningitidis* causing septic arthritis was sequenced. This study provides genomic data for this specific bacterial pathogen linked to joint infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • *Neisseria meningitidis* is a significant bacterial pathogen responsible for various infections.
  • Septic arthritis is a serious joint infection that can be caused by bacterial pathogens.
  • Understanding the genomic characteristics of *N. meningitidis* isolates is crucial for public health and disease management.

Purpose of the Study:

  • To report the complete genome sequence of an *N. meningitidis* isolate.
  • To characterize the genomic features of a strain obtained from a patient with primary meningococcal septic arthritis.

Main Methods:

  • Whole genome sequencing of the *N. meningitidis* isolate.
  • Bioinformatic analysis for genome assembly and characterization.

Main Results:

  • The complete genome sequence of an *N. meningitidis* strain was successfully assembled.
  • The genome size is 2,242,622 base pairs with a GC content of 51.75%.
  • The isolate was identified as belonging to sequence type 17488 of the ST-11 clonal complex.

Conclusions:

  • This study provides the first complete genome sequence for an *N. meningitidis* strain causing septic arthritis.
  • The genomic data can aid in understanding the pathogenesis and evolution of *N. meningitidis* in joint infections.
  • Further research can utilize this genome data for epidemiological surveillance and the development of targeted interventions.
Keywords:
Neisseria meningitidishybrid assemblyseptic arthritis

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