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Case 340
Nuno Lupi Manso1,2, José Laert1, Tomás França de Santana1
1Department of Radiology, Hospital CUF Tejo, Avenida 24 de Julho 171A, 1350-352 Lisbon, Portugal.
Radiology
|April 29, 2025
Summary
This case study highlights a patient with Crohn disease who developed pulmonary complications after infliximab treatment. Further investigation is crucial for diagnosing and managing these unexpected lung issues in inflammatory bowel disease patients.
Area of Science:
- Gastroenterology
- Pulmonology
- Immunology
Background:
- Crohn disease is a chronic inflammatory bowel disease.
- Infliximab is a common biologic therapy for Crohn disease.
- Pulmonary complications are rare but serious adverse events associated with infliximab therapy.
Purpose of the Study:
- To present a case of a Crohn disease patient who developed pleuritic chest pain and dyspnea.
- To investigate the potential pulmonary manifestations of Crohn disease treatment.
Main Methods:
- A case report detailing a 36-year-old woman with Crohn disease.
- Review of medical history, including infliximab and subsequent azathioprine/mesalazine treatment.
- Serial imaging with abdominal and chest CT scans.
- Clinical presentation and diagnostic workup for respiratory symptoms.
Main Results:
- The patient experienced pleuritic chest pain and dyspnea.
- Chest CT revealed lung lesions.
- Biopsy was recommended to investigate the nature of the lung lesions.
Conclusions:
- Pulmonary complications should be considered in Crohn disease patients presenting with respiratory symptoms, especially after biologic therapy.
- Multidisciplinary evaluation involving gastroenterology and pulmonology is essential.
- Further investigation is needed to determine the exact cause and optimal management of these pulmonary findings.
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