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Related Experiment Videos

Red cell sorbitol and diabetic control.

S Akgün, N H Ertel, F W Kemp

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |July 1, 1985
    PubMed
    Summary
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    Red blood cell sorbitol levels correlate with simultaneous plasma glucose in some diabetics. However, this measurement offers no additional clinical information for managing diabetes.

    Area of Science:

    • Endocrinology
    • Metabolic Research
    • Clinical Chemistry

    Background:

    • Disagreement exists regarding the utility of red blood cell sorbitol as a marker for diabetic control.
    • Assessing glycemic control in diabetes mellitus is crucial for preventing long-term complications.

    Purpose of the Study:

    • To evaluate the correlation between red blood cell sorbitol levels and plasma glucose in insulin-dependent diabetic patients.
    • To determine if red cell sorbitol measurements provide additional clinical insights beyond simultaneous plasma glucose readings.

    Main Methods:

    • Studied 7 insulin-dependent diabetic patients over 10-day and 24-hour periods.
    • Collected blood samples at frequent intervals (4-6 hours or 1-4 hours).
    • Analyzed sequential plasma glucose and red cell sorbitol levels for correlation.

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    Main Results:

    • A significant correlation was observed between simultaneous plasma glucose and red cell sorbitol levels (r=0.534, P<.001) in a 10-day study.
    • In 24-hour studies, 3 out of 6 patients showed strong correlations between simultaneous measurements (r=0.727 to 0.957).
    • Correlations were weaker when comparing plasma glucose to later red cell sorbitol measurements.

    Conclusions:

    • Red blood cell sorbitol correlates with simultaneous plasma glucose in some, but not all, diabetic individuals.
    • Red cell sorbitol measurement does not appear to offer additional valuable information for clinicians managing diabetes.
    • Further research may be needed to clarify the role of red cell sorbitol in specific diabetic populations.