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Antioxidant Supplementation in Childhood Obesity: A Path to Improved Metabolic Health?

Ancuta Lupu1, Cristina Maria Mihai2, Felicia Dragan3

  • 1Pediatrics, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Antioxidants (Basel, Switzerland)
|April 29, 2025
PubMed

Insights

Antioxidant supplements may benefit obese children by reducing oxidative stress and improving metabolic health. Further research is needed to confirm long-term safety and effectiveness in pediatric obesity management.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Cardiovascular Health

Background:

  • Childhood obesity is associated with increased oxidative stress, leading to endothelial dysfunction, inflammation, and metabolic issues.
  • Antioxidants, such as Vitamins C and E, play a crucial role in combating free radicals and reducing oxidative damage.

Purpose of the Study:

  • To review the potential benefits of antioxidant supplementation in pediatric obesity.
  • To assess the impact of antioxidants on vascular health, insulin sensitivity, and inflammation in obese children.

Main Methods:

  • Non-systematic review of existing literature.
  • Focus on studies investigating antioxidant supplementation in pediatric obesity.

Main Results:

  • Emerging evidence suggests antioxidants may enhance endothelial function and reduce blood pressure in obese children.
  • Antioxidant use may contribute to improved metabolic homeostasis.

Conclusions:

  • Antioxidant supplementation shows promise for managing obesity-related complications in children.
  • Further randomized controlled trials are essential to establish long-term efficacy and safety.

Keywords:
antioxidantschildrenobesityoxidative stresssupplementation

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