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Related Experiment Video

Updated: May 9, 2025

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14⁺ Monocytes

Published on: April 11, 2025

RORγt eTACs mediate oral tolerance and Treg induction.

Im-Hong Sun^1,2, Anita E Qualls², Han S Yin²

¹Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

The Journal of Experimental Medicine

|April 29, 2025

Summary

This summary is machine-generated.

RORγt-lineage cells, specifically RORγt+ Aire-expressing cells (R-eTACs), are crucial for oral tolerance. These cells, expressing integrin β8, induce regulatory T cells to prevent unwanted immune responses to food antigens.

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Last Updated: May 9, 2025

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Published on: August 13, 2013

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Area of Science:

Immunology
Cell Biology
Oral Tolerance

Background:

The immune system distinguishes pathogens from dietary antigens, but mechanisms are unclear.
Oral tolerance prevents immune responses to food, crucial for health.

Purpose of the Study:

Identify cellular players in oral tolerance.
Investigate the role of RORγt-lineage antigen-presenting cells (APCs).

Main Methods:

Lineage tracing and single-cell sequencing.
Investigated RORγt-lineage APC populations: ILC3s, RORγt+ DCs, and RORγt+ Aire-expressing cells (R-eTACs).
Assessed the necessity of R-eTACs, MHCII, and integrin β8 (Itgb8) for oral tolerance.

Main Results:

R-eTACs, not ILC3s, are essential for oral tolerance induction.
R-eTACs, likely myeloid-derived, uniquely express Itgb8.
MHCII and Itgb8 on RORγt-lineage cells are required for inducing food-specific regulatory T cells (Tregs).
Absence of R-eTACs or MHCII/Itgb8 deletion leads to T-follicular helper responses and increased antibodies.

Conclusions:

R-eTACs are critical mediators of oral tolerance.
Suggests R-eTACs, MHCII, and Itgb8 as novel targets for modulating immune tolerance.