BDNF mediates the heart-brain axis: implications for cardiovascular diseases and mental disorders
Fan Huang1, Jiahao Duan1, Wei Liu1
1Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Insights
Brain-derived neurotrophic factor (BDNF) is key in cardiovascular diseases (CVDs) and mental disorders (MD) comorbidity. Understanding BDNF
Area of Science:
- Neuroscience
- Cardiology
- Psychiatry
Background:
- Cardiovascular diseases (CVDs) and mental disorders (MD) frequently co-occur, impacting patient outcomes.
- The heart-brain axis is crucial in the interplay between CVDs and MD.
- Brain-derived neurotrophic factor (BDNF) is increasingly recognized for its role in both systems.
Purpose of the Study:
- To review the mechanisms of BDNF in heart-brain comorbidity.
- To explore BDNF's influence on inflammation, oxidative stress, and neuroendocrine regulation.
- To discuss clinical applications and drug development related to BDNF.
Main Methods:
- Systematic review of existing literature on BDNF, CVDs, and MD.
- Analysis of BDNF's signaling pathways, including TrkB receptor interactions.
- Examination of BDNF's role in regulating inflammatory, oxidative, and neuroendocrine responses.
Main Results:
- BDNF modulates inflammation, oxidative stress (OS), and the hypothalamic-pituitary-adrenal (HPA) axis.
- These regulatory functions are central to the pathogenesis of comorbid CVDs and MD.
- BDNF shows potential as a diagnostic and therapeutic target.
Conclusions:
- BDNF is a critical mediator in the heart-brain axis, influencing the comorbidity of CVDs and MD.
- Targeting BDNF offers promising strategies for novel diagnostic and therapeutic interventions.
- Further research into BDNF's role can advance prevention and treatment approaches for these conditions.
Abstract:
The comorbidity of cardiovascular diseases (CVDs) and mental disorders (MD) has become a significant challenge in modern medicine, severely affecting patients' quality of life and prognosis. The heart-brain axis, a bidirectional pathway connecting the central nervous system and the cardiovascular system, plays a critical role in the comorbidity mechanisms of CVDs and MD. In recent years, brain-derived neurotrophic factor (BDNF) has emerged as a key molecule in the study of CVDs and MD. By binding with high affinity to TrkB receptors and activating various signaling pathways, BDNF exerts multiple functions in both the nervous and cardiovascular systems. BDNF may participate in the pathogenesis of CVDs combined with MD through multiple mechanisms such as regulating inflammatory responses, oxidative stress (OS), and the hypothalamic-pituitary-adrenal (HPA) axis, making it a promising new target for future diagnosis and treatment. This review systematically summarizes the mechanisms by which BDNF functions in heart-brain comorbidity, particularly its multifaceted influence on inflammation, OS, and neuroendocrine regulation. Additionally, we discuss the clinical application prospects of BDNF in disease diagnosis and treatment, as well as progress in related drug development. A deeper understanding of BDNF's role in the heart-brain axis will provide new insights and strategies for the prevention, diagnosis, and treatment of CVDs and MD.
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