Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution.
Ganna Nevoit1, Gediminas Jarusevicius1, Maksim Potyazhenko2
1Laboratory for Automatization of Cardiovascular Investigations, Cardiology Institute, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Biomedicines
|April 29, 2025
Summary
Mitochondrial dysfunction (MD) is a primary driver of atherosclerosis development and progression. Understanding these shared molecular mechanisms is crucial for preventing atherosclerosis through a healthy lifestyle and developing new diagnostic and treatment strategies.
Area of Science:
- Cardiovascular Science
- Mitochondrial Biology
- Pathogenesis Research
Background:
- Atherosclerosis is a complex disease with multifactorial origins.
- Mitochondrial dysfunction (MD) has emerged as a significant factor in disease pathogenesis.
- Interdisciplinary research is needed to fully understand the link between MD and atherosclerosis.
Purpose of the Study:
- To review the current understanding of mitochondrial dysfunction's role in atherosclerosis.
- To highlight the molecular mechanisms connecting MD and atherosclerosis.
- To guide future clinical applications and research directions.
Main Methods:
- Comprehensive literature review.
- Analysis of molecular mechanisms underlying MD and atherosclerosis.
- Synthesis of existing research findings.
Main Results:
- Mitochondrial dysfunction (MD) is identified as a core cause and mechanism in atherosclerosis.
- Atherosclerosis pathogenesis can be viewed through the lens of MD.
- MD and atherosclerosis share common molecular pathways.
Conclusions:
- MD and atherosclerosis are intrinsically linked by shared molecular pathogenesis.
- Promoting a healthy lifestyle is essential for atherosclerosis prevention, informed by MD knowledge.
- Developing novel diagnostic and therapeutic approaches for MD in atherosclerosis is a critical scientific challenge.
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