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Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
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Plausible Deniable Medical Image Encryption by Large Language Models and Reversible Content-Aware Strategy.

Yirui Wu, Xinfu Liu, Lucia Cascone

    IEEE Journal of Biomedical and Health Informatics
    |April 29, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel medical image encryption method using Large Language Models (LLMs) to enhance DNA encoding. The LLM-enhanced DNA encoding offers superior security and efficiency for protecting sensitive patient data.

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    Area of Science:

    • Computer Science
    • Medical Imaging
    • Cryptography

    Background:

    • Healthcare systems face significant security risks, with data loss potentially causing severe harm to patients and institutions.
    • DNA encoding presents a promising solution for medical image encryption due to its speed, parallelism, minimal storage, and robust security.

    Purpose of the Study:

    • To propose an advanced medical image encryption technique by integrating Large Language Models (LLMs) with DNA encoding.
    • To enhance the security and efficiency of medical image data protection against privacy breaches.

    Main Methods:

    • The proposed method features an LLM enhancing module to compress low-entropy medical image pixels into compact, probabilistic signals, adding a layer of defense.
    • A content-aware permutation and diffusion module further secures data by breaking pixel correlations and increasing cryptographic complexity via DNA-based diffusion.

    Main Results:

    • Experiments on ChestXray-14, COVID-CT, and fcon-1000 datasets demonstrated superior performance compared to existing methods.
    • The LLM-enhanced DNA encoding method showed significant improvements in sensitivity, correlation, and entropy metrics.

    Conclusions:

    • The LLM-enhanced DNA encoding method provides a highly effective and secure approach for medical image encryption.
    • This technique offers a robust solution for safeguarding sensitive medical data in healthcare systems.