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A prospective study of comparing waist circumference and BMI as predictors for the kidney damage progression

  • 0Department of Clinical Trials and Clinical Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Plos One +

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April 29, 2025

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April 29, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Waist circumference (WC) predicts kidney damage progression in males, but body mass index (BMI) remains a reliable indicator for both sexes. Maintaining healthy BMI and WC is crucial for kidney health.

Area Of Science

  • Nephrology
  • Public Health
  • Endocrinology

Background

  • Chronic kidney disease (CKD) is irreversible and impacts quality of life.
  • Obesity, often measured by body mass index (BMI), is a known risk factor for CKD progression.
  • Waist circumference (WC), reflecting abdominal adiposity, is proposed as an alternative obesity indicator.

Purpose Of The Study

  • To investigate if waist circumference (WC) can predict kidney damage progression.
  • To compare WC's predictive ability against body mass index (BMI).

Main Methods

  • Prospective study of 4,129 individuals with normal kidney function (2016-2019).
  • Collected baseline data on BMI, WC, lifestyle, and comorbidities.
  • Monitored participants until 2023 for kidney damage progression, analyzing WC and BMI associations.

Main Results

  • WC indicated a higher risk of kidney damage progression in males (HR=1.01-1.39).
  • These associations were not significant in females.
  • After adjusting for BMI, WC's predictive value diminished.
  • Overweight males (BMI ≥ 25 kg/m²) showed a significantly increased risk (HR = 1.69).

Conclusions

  • Waist circumference is a significant factor in kidney damage progression for males.
  • Body mass index remains a dependable predictor of kidney damage.
  • Maintaining healthy BMI and WC is essential for reducing CKD progression risk.

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