Noninvasive Hemodynamic Assessment by a Sensor Patch: The PATCHWRK (PortAble TeCHnology for Wireless caRdiomyopathy...

Area of Science:

• Cardiology
• Biomedical Engineering
• Medical Devices

Background:

• Echocardiographic timing intervals offer prognostic insights into preclinical cardiac dysfunction.
• Reduced diastolic filling time (DFT) is linked to cardiomyopathy risk in left bundle branch block patients.
• Current echocardiography limitations hinder longitudinal assessment due to specialized equipment needs.

Purpose of the Study:

• To evaluate a multimodal sensor patch (SANSA) for assessing cardiac timing intervals.
• Specifically assessing diastolic filling time (DFT), pre-ejection period (PEP), and left ventricular ejection time (LVET).

Main Methods:

• Prospective enrollment of 50 patients undergoing echocardiography.
• Simultaneous recording using the SANSA patch and echocardiography.
• Analysis of timing intervals via continuous wave, pulsed wave, and tissue Doppler imaging, alongside SANSA's ECG, seismocardiogram, and phonocardiogram data.
• Agreement assessment using intraclass correlation coefficients (ICC).

Main Results:

• Analyzable data obtained from 92% of patients (46/50).
• SANSA showed high agreement with echocardiography: ICC of 0.92 for DFT, 0.74 for PEP, and 0.76 for LVET.
• SANSA-derived intervals were comparable to those obtained between different echocardiographic views.

Conclusions:

• The SANSA patch provides accurate measurements of cardiac timing intervals, comparable to echocardiography.
• This wearable technology may enable early detection of cardiomyopathy through longitudinal monitoring.