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Updated: May 17, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
Effect of type 2 diabetes mellitus microenvironment on osteogenic capacity of bone marrow mesenchymal stem cells
Yanling Mi1, Danni Wei1, Bingli Du1
1Shanxi Medical University, School and Hospital of Stomatology, Taiyuan 030001, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, China.
Abstract:
Type 2 diabetes mellitus (T2DM) often leads to delayed bone regeneration such as slow healing of fractures and bone defects. The number, status and osteogenic differentiation capacity of bone marrow mesenchymal stem cells (BMSCs) are extremely important in bone healing and bone regeneration. The T2DM microenvironment can have irreversible negative effects on BMSCs. In this paper, we review the molecular expression and altered proliferation, migration, and osteogenic differentiation capacity of BMSCs in the microenvironment of T2DM, it provides a new perspective to restore the normal function of T2DM-BMSCs, so as to save the damaged bone regeneration capacity.
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