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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
[Immunodeficiency and related infections caused by anti-cytokine autoantibody]
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Abstract:
Anti-cytokine autoantibody (AAb) is produced by plasma cells and interfere with the signaling pathways of their respective cytokines, thereby blocking the biological functions of these target cytokines. This disruption increases the susceptibility of patients to pathogens, leading to recurrent and complex infections. Known anti-cytokine autoantibodies include those against interferon, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, IL-17, and IL-12/23. These antibodies are associated with immune deficiency-related infections. This review summarizes the clinical manifestations and underlying mechanisms of these diseases.
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