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Published on: January 29, 2018

Different Causes of a Transient Loss of Consciousness with Convulsions between Two Young Sisters: Epilepsy and Type-2

Hiroshi Hasegawa1, Tadashi Nakajima1, Hideyuki Kawauchi2

  • 1Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|April 29, 2025
PubMed

A misdiagnosis of syncope as a seizure can lead to catastrophic outcomes, and thus should be avoided. We herein present the cases of two young sisters who experienced transient loss of consciousness with convulsions and were diagnosed with epilepsy. After discovering that their asymptomatic mother had type-2 long QT syndrome (LQT2), it was found that the younger sister had LQT2, while the older sister did not. Although the 12-lead ECG of the younger sister showed notched T-waves, the corrected QT interval (422 ms) was normal, which precluded a diagnosis of LQT2. These cases provide clues to distinguish between LQT2-related arrhythmic events and epileptic events.

Keywords:
KCNH2LQT2convulsionepilepsygenetic testingsyncope

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