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Rheumatoid Arthritis That Developed in a Patient with Ulcerative Colitis During Adalimumab Therapy: A Case Report and
Takeshi Zoshima1,2, Makoto Horita1,2, Hiroyuki Kawahara1,2
1Department of Internal Medicine, Asanogawa General Hospital, Japan.
Rheumatoid arthritis (RA) is a rare complication of ulcerative colitis (UC). This case study highlights a patient who developed RA during tumor necrosis factor (TNF) inhibitor therapy for UC, suggesting RA can occur despite such treatments.
Area of Science:
- Gastroenterology
- Rheumatology
- Immunology
Background:
- Ulcerative colitis (UC) patients on tumor necrosis factor (TNF) inhibitors may experience joint issues.
- Rheumatoid arthritis (RA) is an uncommon manifestation in UC patients, particularly during anti-TNF therapy.
Purpose of the Study:
- To report a rare case of seropositive rheumatoid arthritis (RA) developing during adalimumab therapy for ulcerative colitis (UC).
- To review existing literature on the co-occurrence of UC and RA and the impact of TNF inhibitors.
Main Methods:
- Case report of a 70-year-old woman with UC treated with adalimumab.
- Literature review of 30 patients diagnosed with both UC and RA.
Main Results:
- The patient developed seropositive RA while on adalimumab for UC.
- Literature review identified three patients (10%) with RA developing after UC diagnosis.
- This is the first reported case of RA developing during TNF inhibitor therapy for UC.
Conclusions:
- Rheumatoid arthritis can develop in UC patients even when treated with TNF inhibitors.
- This finding underscores the importance of considering RA as a differential diagnosis for arthritis in UC patients, irrespective of anti-TNF treatment.
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