NeuroXiv: AI-powered open databasing and dynamic mining of brain-wide neuron morphometry
Shengdian Jiang1,2, Lijun Wang1,3, Zhixi Yun1,2
1New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Nature Methods
|April 29, 2025
Abstract:
Neuron morphology has been extensively reconstructed at the whole-brain scale by various projects in recent years. Here, to facilitate interactive exploration in a standardized and scalable manner, we introduce NeuroXiv (neuroxiv.org), a large-scale database containing 175,149 reconstructed neuron morphologies mapped to the Common Coordinate Framework Version 3 (CCFv3). In addition, NeuroXiv incorporates an AI-powered mining engine (AIPOM) for dynamic, user-specific data mining, delivering enhanced performance via a custom client program.
